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Literature summary for 1.2.4.4 extracted from

  • Chang, C.F.; Chou, H.T.; Chuang, J.L.; Chuang, D.T.; Huang, T.H.
    Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex (2002), J. Biol. Chem., 277, 15865-15873.
    View publication on PubMed
Search for more literature for 1.2.4.4

Cloned(Commentary)

Cloned (Comment) Organism
expression of the lipoic acid-bearing domain of complex component E2 in Escherichia coli strain BL21(DE3) as His-tagged protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the lipoic acid-bearing domain of enzyme complex component E2 plays a central role in substrate channeling in the mitochondrial multienzyme complex ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 the lipoic acid-bearing domain is part of the E2 transacylase subunit of the branched-chain alpha-keto acid dehydrogenase complex
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Purification (Commentary)

Purification (Comment) Organism
recombinant lipoic acid-bearing domain of complex component E2 from Escherichia coli strain BL21(DE3) as His-tagged protein by nickel affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the lipoic acid-bearing domain of enzyme complex component E2 plays a central role in substrate channeling in the mitochondrial multienzyme complex Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More lipoic acid-bearing domain of complex component E2: NMR secondary structure determination and analysis, a flattened beta-barrel formed by two 4-stranded antiparallel beta-sheets, loops connecting the beta-strands, tertiary fold, structure dynamics, complex component E2 structure, overview Homo sapiens