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Literature summary for 1.2.4.4 extracted from
- Branched-chain amino acid catabolism in exercise and liver disease (2006), J. Nutr., 136, 250S-253S.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| alpha-Ketoisocaproate | promotes dissociation of the BCKDH kinase from the BCKDH complex, consistent with activation of BCKDH complex | Rattus norvegicus |  |
| additional information | endurance exercise activates the BCKDH complex | Homo sapiens | |
| additional information | endurance exercise activates the BCKDH complex | Rattus norvegicus | |
| tumor necrosis factor-alpha | promotes dissociation of the BCKDH kinase from the BCKDH complex in rat liver, resulting in activation of the BCKDH complex | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | activation of the BCKDH complex appears responsible for the increase in branched-chain amino acid catabolism caused by exercise and liver cirrhosis, branched-chain amino acid administration improves protein turnover in humans with liver cirrhosis, suggesting that branched-chain amino acid supplements are appropriate for patients with liver cirrhosis, branched-chain amino acid administration in patients with acute liver failure, especially those with high serum branched-chain amino acid concentrations, may not be appropriate because of the likelihood of branched-chain amino acid overload | Homo sapiens |
| medicine | activation of the BCKDH complex appears responsible for the increase in branched-chain amino acid catabolism caused by exercise and liver cirrhosis, branched-chain amino acid administration improves protein turnover in rats with liver cirrhosis, suggesting that branched-chain amino acid supplements are appropriate for patients with liver cirrhosis | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Homo sapiens | - |
| skeletal muscle | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BCKDH | - |
Homo sapiens |
| BCKDH | - |
Rattus norvegicus |
| branched-chain alpha-keto acid dehydrogenase complex | - |
Homo sapiens |
| branched-chain alpha-keto acid dehydrogenase complex | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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