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Literature summary for 1.2.4.4 extracted from

  • Tso, S.C.; Qi, X.; Gui, W.J.; Chuang, J.L.; Morlock, L.K.; Wallace, A.L.; Ahmed, K.; Laxman, S.; Campeau, P.M.; Lee, B.H.; Hutson, S.M.; Tu, B.P.; Williams, N.S.; Tambar, U.K.; Wynn, R.M.; Chuang, D.T.
    Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (2013), Proc. Natl. Acad. Sci. USA, 110, 9728-9733.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
(S)-2-chlorophenylpropionic acid
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-chloro-phenylpropionic acid
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoisocaproate + NAD+ + CoA Mus musculus
-
 3-methylbutanoyl-CoA + CO2 + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoisocaproate + NAD+ + CoA
-
 Mus musculus 3-methylbutanoyl-CoA + CO2 + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
BCKDC
-
 Mus musculus
branched-chain alpha-ketoacid dehydrogenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus