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Literature summary for 1.2.4.4 extracted from

  • Singh, V.K.; Sirobhushanam, S.; Ring, R.P.; Singh, S.; Gatto, C.; Wilkinson, B.J.
    Roles of pyruvate dehydrogenase and branched-chain alpha-keto acid dehydrogenase in branched-chain membrane fatty acid levels and associated functions in Staphylococcus aureus (2018), J. Med. Microbiol., 67, 570-578 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.4.4

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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Staphylococcus aureus JE2
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Synonyms

Synonyms Comment Organism
Bkd
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 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function branched-chain fatty acids make up 50% of membrane fatty acids in wild-type but only 31% in the branched-chain alpha-keto acid dehydrogenase BKD-deficient mutant. Branched-chain fatty acids level is about 80% in the pyruvate dehydrogenase PDH-deficient strain and 38% in the BKD:pruvate dehydrogenase-deficient strain. BKD-deficient mutants show decreased membrane fluidity,while the PDH-deficient mutant shows increased membrane fluidity. The BKD- and PDH-deficient strains grow slower and the BKD:PDH-deficient strain grows slowest at 37°C. The BKD-deficient strain produces higher levels of staphyloxanthin. The PDH-deficient and BKD:PDH-deficient strains produce very little staphyloxanthin. The BKD-deficient strain shows increased susceptibility to daptomycin Staphylococcus aureus