Literature summary for 1.2.7.6 extracted from

Hagedoorn, P.L.
Steady-state kinetics of the tungsten containing aldehyde ferredoxin oxidoreductases from the hyperthermophilic archaeon Pyrococcus furiosus (2019), J. Biotechnol., 306, 142-148 .

Search for more literature for 1.2.7.6

Activating Compound

Activating Compound	Comment	Organism	Structure
NaCl	enzyme shows partial substrate inhibition, inhibition is alleviated completely by a 1M NaCl resulting in increased enzyme activity at high substrate concentrations	Pyrococcus furiosus

Inhibitors

Inhibitors	Comment	Organism	Structure
D-glyceraldehyde 3-phosphate	partial substrate inhibition, inhibition is alleviated completely by a 1M NaCl resulting in increased enzyme activity at high substrate concentrations	Pyrococcus furiosus

Organism

Organism	UniProt	Comment	Textmining
Pyrococcus furiosus	Q8U3K2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glyceraldehyde 3-phosphate + H2O + 2 oxidized benzyl viologen	D-glyceraldehyde 3-phosphate is the only substrate oxidized by GAPOR, and the kinetics of the enzyme are unaffected by the presence of L-glyceraldehyde 3-phosphate	Pyrococcus furiosus	3-phospho-D-glycerate + 2 H+ + 2 reduced benzyl viologen	-	?
additional information	substrate glyceraldehyde-3-phosphate degrades at 60°C by non-enzymatic elimination of the phosphate group to methylglyoxal with a half-life of 6.5 min. Methylglyoxal is not a substrate or inhibitor of GAPOR	Pyrococcus furiosus	?	-	-

Synonyms

Synonyms	Comment	Organism
Gor	-	Pyrococcus furiosus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9	-	at pH 9, the substrate is a divalent anion	Pyrococcus furiosus

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Release 2023.1 (January 2023)