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Literature summary for 1.21.3.3 extracted from

  • Kutchan, T.M.; Dittrich, H.
    Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants (1995), J. Biol. Chem., 270, 24475-24481.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Spodoptera frugiperda Sf9 cells Eschscholzia californica

Protein Variants

Protein Variants Comment Organism
H104T no activity Eschscholzia californica
H308S 5% activity of wild-type Eschscholzia californica
H39G 40% activity of wild-type Eschscholzia californica
R100T no activity Eschscholzia californica

Inhibitors

Inhibitors Comment Organism Structure
(S)-scoulerine 50% inhibition at 0.01 mM Eschscholzia californica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-reticuline + O2 Eschscholzia californica
-
(S)-scoulerine + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Eschscholzia californica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R,S)-6-O-methyllaudanosoline + O2
-
Eschscholzia californica ? + H2O2
-
?
(R,S)-crassifoline + O2
-
Eschscholzia californica ? + H2O2
-
?
(R,S)-laudanosoline + O2 specific for the (S)-enantiomer Eschscholzia californica ? + H2O2
-
?
(S)-N-methylcoclaurine + O2
-
Eschscholzia californica (S)-coclaurine + H2O2
-
?
(S)-protosinomenine + O2
-
Eschscholzia californica ? + H2O2
-
?
(S)-reticuline + O2
-
Eschscholzia californica (S)-scoulerine + H2O2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.5
-
-
Eschscholzia californica

Cofactor

Cofactor Comment Organism Structure
FAD 1 mol per mol protein Eschscholzia californica
FAD covalently attached to His104 Eschscholzia californica