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Literature summary for 1.21.99.4 extracted from

  • Garcia-Macias, J.F.; Molinero, P.; Guerrero, J.M.; Osuna, C.
    Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes (1994), FEBS Lett., 354, 110-112.
    View publication on PubMed
Search for more literature for 1.21.99.4

Activating Compound

Activating Compound Comment Organism Structure
isoproterenol type II Rattus sp.
additional information hypothyroidism enhances type II activity and decreases type I activity Rattus sp.

Cloned(Commentary)

Cloned (Comment) Organism
translation of purified rat RNA in Xenopus laevis oocytes Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
ipanoic acid type II Rattus sp.
propanolol type II Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001 0.005 L-thyroxine type II Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Homo sapiens
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain thyronine 5'-deiodinase type II Rattus sp.
-
brown adipose tissue thyronine 5'-deiodinase type II Rattus sp.
-
harderian gland thyronine 5'-deiodinase type II Rattus sp.
-
hypophysis thyronine 5'-deiodinase type II Rattus sp.
-
keratinocyte thyronine 5'-deiodinase type II Rattus sp.
-
kidney
-
 Rattus sp.
-
liver
-
 Homo sapiens
-
liver thyronine 5'-deiodinase type I Rattus sp.
-
pineal gland thyronine 5'-deiodinase type II Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2
-
 Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
iodothyronine 5'-deiodinase type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) Rattus sp.