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Literature summary for 1.21.99.4 extracted from

  • Leonard, J.L.; Visser, T.J.; Leonard, D.M.
    Characterization of the subunit structure of the catalytically active type I iodothyronine deiodinase (2001), J. Biol. Chem., 276, 2600-2607.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in LLC-PK1 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein. Once assembled the D1 holoenzyme is sorted to the plasma membrane in both kidney and liver cells, where it can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell Rattus norvegicus 16020
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
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2 * 27000 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Rattus norvegicus in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell 3,3',5-triiodothyronine + iodide + A + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P24389
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-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
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Rattus norvegicus
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liver
-
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 in kidney and liver cells the enzyme can serve as an enzymic barrier to the entry of the prohormone thyroxine and the source of bioactive 3,3',5-triiodothyronine for the cell Rattus norvegicus 3,3',5-triiodothyronine + iodide + A + H+
-
?
L-thyroxine + electron acceptor
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Rattus norvegicus 3,3',5-triiodothyronine + iodide + reduced electron acceptor
-
?

Subunits

Subunits Comment Organism
dimer 2 * 27000 Rattus norvegicus

Synonyms

Synonyms Comment Organism
type I iodothyronine deiodinase
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Rattus norvegicus