Literature summary for 1.21.99.4 extracted from

Piekielko-Witkowska, A.; Master, A.; Wojcicka, A.; Boguslawska, J.; Brozda, I.; Tanski, Z.; Nauman, A.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer (2009), Thyroid, 19, 1105-1113.

Search for more literature for 1.21.99.4

Application

Application	Comment	Organism
medicine	expression and alternative splicing of DIO mRNA is disturbed in renal cancer, possibly due to changes in expression of splicing factors SF2/ASF and hnRNPA1	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
different splicing variants of DOI1 are cloned into the vector pGEM-T for sequencing, 11 variants are identified	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
selenium	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-thyroxine + AH2	Homo sapiens	activation and deactivation of thyroid hormone	3,5,3'-triiodo-L-thyronine + iodide + A + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49895	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Homo sapiens	-
renal cell carcinoma cell	ccRCC	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-thyroxine + AH2	activation and deactivation of thyroid hormone	Homo sapiens	3,5,3'-triiodo-L-thyronine + iodide + A + H+	-	r

Synonyms

Synonyms	Comment	Organism
DIO1	-	Homo sapiens
type 1 iodothyronine deiodinase	-	Homo sapiens

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Release 2023.1 (January 2023)