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Literature summary for 1.21.99.4 extracted from
- Radiometric enzyme assays: development of methods for extremely sensitive determination of types 1, 2 and 3 iodothyronine deiodinase enzyme activities (2010), J. Radioanal. Nucl. Chem., 286, 861-865.
No PubMed abstract available
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | integral membrane protein | Rattus norvegicus | 16020 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | selenoprotein | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astroglial cell | - |
Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,3',5'-triiodothyronine + AH2 | substrate for type 1 iodothyronine deiodinase | Rattus norvegicus | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
| L-thyroxine + AH2 | substrate for type 2 iodothyronine deiodinase | Rattus norvegicus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| type 1 iodothyronine deiodinase | - |
Rattus norvegicus |
| type 2 iodothyronine deiodinase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | incubation (for 2-12 h at 37°C) of confluent primary cultures of astroglial cells, maintained in a chemically defined medium devoid of growth factors and hormones, with various concentrations of adenosine, AMP, ADP, ATP (highest activity at 0. 1 mM after 4 h), and a series of their analogues causes a marked induction of type 2 iodothyronine deiodinase activity (up to 30fold basal level). Preincubation of cells with all-trans-retinoic acid multiplies the inducing effect of the purines (up to 42fold increase of type 1 iodothyronine deiodinase); all-trans retinoic acid itself enhances the activity of type 2 iodothyronine deiodinase, and also of type 1 iodothyronine deiodinase, only a little | up |
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Release 2023.1 (January 2023)
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