Application | Comment | Organism |
---|---|---|
medicine | target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
interferon-alpha-2a | cell lines CAL 27, CAL 33, CAL 51, CAL 7, PANC 3 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | Homo sapiens | - |
5-fluoro-5,6-dihydrouracil + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | cell line CAL 7 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.118 | - |
cell line CAL 27 | Homo sapiens |
0.122 | - |
cell line CAL 7 | Homo sapiens |
0.184 | - |
cell line CAL 33 | Homo sapiens |
0.265 | - |
cell line PANC 3 | Homo sapiens |
0.318 | - |
cell line CAL 51 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DPD | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |