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Literature summary for 1.3.1.1 extracted from

  • Sadahiro, S.; Suzuki, T.; Maeda, Y.; Ishikawa, K.; Tanaka, Y.; Yasuda, S.; Kamijo, A.; Makuuchi, H.; Murayama, C.
    Dihydropyrimidine dehydrogenase activity during long-term adjuvant treatment with oral uracil and tegafur for colorectal cancer (2007), Chemotherapy, 53, 442-445.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information combined oral treatment with uracil and tegafur has no influence on DPD activity Homo sapiens
Uracil reversible inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral blood mononuclear cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NAD+
-
Homo sapiens alpha-fluoro-beta-alanine + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
dihydropyrimidine dehydrogenase
-
Homo sapiens
DPD
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens