Literature summary for 1.3.1.1 extracted from

van Kuilenburg, A.B.; Klumpen, H.; Westermann, A.M.; Zoetekouw, L.; Van Lenthe, H.; Bakker, P.J.; Richel, D.J.; Guchelaar, H.
Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin (2007), Eur. J. Cancer, 43, 459-465.

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Activating Compound

Activating Compound	Comment	Organism	Structure
leucovorin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
buccal mucosa	-	Homo sapiens	-
peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorouracil + NADH + H+	-	Homo sapiens	5-fluoro-5,6-dihydrouracil + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
dihydropyrimidine dehydrogenase	-	Homo sapiens
DPD	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)