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Literature summary for 1.3.1.1 extracted from
- Possible associations of splice site mutation of dihydropyrimidine dehydrogenase (IVS14+1G>A) in adverse drug reactions in some invasive ductal carcinoma patients (2007), Int. J. Pharmacol., 3, 130-136.
No PubMed abstract available
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the splice-site polymorphism IVS14+1G>A results in severe DPD deficiency with absent DPD activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| breast invasive ductal carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + NADH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NAD+ | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydropyrimidine dehydrogenase | - |
Homo sapiens |
| DPD | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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