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Literature summary for 1.3.1.1 extracted from

  • Zhang, X.; Diasio, R.B.
    Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy (2007), Pharmacogenomics, 8, 257-265.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phorbol-12-myristate activates gene expression Homo sapiens
specificity protein 1 transcription activator Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
2 * 110000, SDS-PAGE Homo sapiens
220000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
colorectal cancer cell
-
Homo sapiens
-
gastric cancer cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
ovary cancer cell
-
Homo sapiens
-
pancreatic cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADH + H+
-
Homo sapiens 5-fluoro-5,6-dihydrouracil + NAD+
-
?
uracil + NADH + H+
-
Homo sapiens 5,6-dihydrouracil + NAD+
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 110000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
dihydropyrimidine dehydrogenase
-
Homo sapiens
DPD
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens