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Literature summary for 1.3.1.100 extracted from

  • Coyle, C.M.; Cheng, J.Z.; OConnor, S.E.; Panaccione, D.G.
    An old yellow enzyme gene controls the branch point between Aspergillus fumigatus and Claviceps purpurea ergot alkaloid pathways (2010), Appl. Environ. Microbiol., 76, 3898-3903.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.100

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
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-
-
Aspergillus fumigatus FGSC A1141
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-
-

Synonyms

Synonyms Comment Organism
EasA
-
 Aspergillus fumigatus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Aspergillus fumigatus

General Information

General Information Comment Organism
malfunction disruption of the easA gene leads to accumulation of chanoclavine-I and chanoclavine-I-aldehyde Aspergillus fumigatus
metabolism the enzyme is required for incorporation of chanoclavine-I-aldehyde into more-complex ergot alkaloids, presumably by reducing the double bond conjugated to the aldehyde group, thus facilitating ring closure Aspergillus fumigatus