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Literature summary for 1.3.1.100 extracted from
- A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis (2017), Org. Biomol. Chem., 15, 8059-8071 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli M15 cells | Penicillium roqueforti |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chanoclavine-I aldehyde + NADPH + H+ | Aspergillus fumigatus | - |
dihydrochanoclavine-I aldehyde + NADP+ | - |
? |  |
| chanoclavine-I aldehyde + NADPH + H+ | Penicillium roqueforti | - |
dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
| chanoclavine-I aldehyde + NADPH + H+ | Penicillium roqueforti FM164 | - |
dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
| chanoclavine-I aldehyde + NADPH + H+ | Aspergillus fumigatus ATCC MYA-4609 | - |
dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus fumigatus | Q4WZ70 | - |
- |
| Aspergillus fumigatus ATCC MYA-4609 | Q4WZ70 | - |
- |
| no activity in Claviceps purpurea | - |
- |
- |
| Penicillium roqueforti | W6Q9S9 | - |
- |
| Penicillium roqueforti FM164 | W6Q9S9 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA agarose resin column chromatography | Penicillium roqueforti |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chanoclavine-I aldehyde + NADPH + H+ | - |
Aspergillus fumigatus | dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
| chanoclavine-I aldehyde + NADPH + H+ | - |
Penicillium roqueforti | dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
| chanoclavine-I aldehyde + NADPH + H+ | - |
Penicillium roqueforti FM164 | dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
| chanoclavine-I aldehyde + NADPH + H+ | - |
Aspergillus fumigatus ATCC MYA-4609 | dihydrochanoclavine-I aldehyde + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, His6-tagged enzyme, SDS-PAGE | Penicillium roqueforti |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FgaOx3 | - |
Aspergillus fumigatus |
| FgaOx3Pr3 | - |
Penicillium roqueforti |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Aspergillus fumigatus | |
| FMN | - |
Penicillium roqueforti | |
| NADPH | - |
Aspergillus fumigatus | |
| NADPH | - |
Penicillium roqueforti | |
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Release 2023.1 (January 2023)
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