Application | Comment | Organism |
---|---|---|
pharmacology | structural investigations of reactive isoniazid species in order to promote the design of new inhibitors of InhA as potential antituberculous drugs | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
overexpressed in Escherichia coli | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isoniazid-coenzyme adduct | inhibition by several types of isoniazid-coenzyme adducts coexisting in solution is discussed in relation with the structure of the coenzyme, the stereochemistry of the adducts, and their existence as both open and cyclic forms | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
enoyl-acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
InhA Protein | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | natural cofactor | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
metabolism | key enzyme involved in the biosynthesis of long-chain fatty acids and of mycolic acids, specific components of the mycobacterial cell wall | Mycobacterium tuberculosis |