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Literature summary for 1.3.1.13 extracted from

  • Byng, G.S.; Berry, A.; Jensen, R.A.
    Evolutionary implications of features of aromatic amino acid biosynthesis in the genus Acinetobacter (1985), Arch. Microbiol., 143, 122-129.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-tyrosine competitive inhibition with respect to substrate and noncompetitively with respect to cofactor Acinetobacter calcoaceticus
NADP+
-
Acinetobacter calcoaceticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
NADP+
-
Acinetobacter calcoaceticus
0.033
-
prephenate
-
Acinetobacter calcoaceticus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
210000
-
gel filtration Acinetobacter calcoaceticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prephenate + NADP+ Acinetobacter calcoaceticus
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+ Acinetobacter sp.
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+ Acinetobacter lwoffii
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+ Acinetobacter sp. C1W
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
?

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
ATCC 14987
-
Acinetobacter calcoaceticus
-
ATCC 23055
-
Acinetobacter lwoffii
-
ATCC 15309
-
Acinetobacter sp.
-
-
-
Acinetobacter sp. C1W
-
-
-

Purification (Commentary)

Purification (Comment) Organism
strain 23055, partially Acinetobacter calcoaceticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prephenate + NADP+
-
Acinetobacter calcoaceticus 4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+
-
Acinetobacter sp. 4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+
-
Acinetobacter lwoffii 4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+
-
Acinetobacter sp. C1W 4-hydroxyphenylpyruvate + CO2 + NADPH
-
?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Acinetobacter calcoaceticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.009
-
L-tyrosine competitive inhibition with respect to substrate and noncompetitively with respect to cofactor Acinetobacter calcoaceticus
0.038
-
NADP+
-
Acinetobacter calcoaceticus