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Literature summary for 1.3.1.13 extracted from

  • Schenck, C.A.; Chen, S.; Siehl, D.L.; Maeda, H.A.
    Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes (2015), Nat. Chem. Biol., 11, 52-57.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by L-Tyr Glycine max
additional information not inhibited by L-Tyr Medicago truncatula

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.127
-
prephenate at 37┬░C, pH not specified in the publication Glycine max
0.223
-
prephenate at 37┬░C, pH not specified in the publication Medicago truncatula

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prephenate + NADP+ Glycine max
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+ Medicago truncatula
-
4-hydroxyphenylpyruvate + CO2 + NADPH
-
?

Organism

Organism UniProt Comment Textmining
Glycine max
-
-
-
Medicago truncatula
-
-
-
no activity in Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Glycine max
-
leaf
-
Medicago truncatula
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prephenate + NADP+
-
Glycine max 4-hydroxyphenylpyruvate + CO2 + NADPH
-
?
prephenate + NADP+
-
Medicago truncatula 4-hydroxyphenylpyruvate + CO2 + NADPH
-
?

Synonyms

Synonyms Comment Organism
PDH1
-
Glycine max
PDH1
-
Medicago truncatula
TyrAp
-
Glycine max
TyrAp
-
Medicago truncatula

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
21.8
-
prephenate at 37┬░C, pH not specified in the publication Medicago truncatula
26.3
-
prephenate at 37┬░C, pH not specified in the publication Glycine max

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Glycine max
NADP+
-
Medicago truncatula

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
100
-
prephenate at 37┬░C, pH not specified in the publication Medicago truncatula
217
-
prephenate at 37┬░C, pH not specified in the publication Glycine max