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Literature summary for 1.3.1.2 extracted from

  • Porter, D.J.T.; Spector, T.
    Dihydropyrimidine dehydrogenase. Kinetic mechanism for reduction of uracil by NADPH (1993), J. Biol. Chem., 268, 19321-19327.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-Ethynyluracil suicide inactivator covalently modifying a cysteinyl residue Bos taurus
NADP+ competitive versus NADPH Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00012
-
NADPH
-
Bos taurus
0.00012
-
Uracil
-
Bos taurus
0.0004
-
NADP+ in presence of 5,6-dihydrouracil Bos taurus
0.0008
-
Uracil cofactor NADPH Bos taurus
0.24
-
5,6-dihydrouracil in presence of NADP+ Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ random rapid-equilibrium mechanism Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,6-dihydrouracil + NADP+
-
Bos taurus uracil + NADPH
-
r
thymine + NADPH
-
Bos taurus dihydrothymine + NADP+
-
r
uracil + NADPH
-
Bos taurus 5,6-dihydrouracil + NADP+
-
r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.4
-
5,6-dihydrouracil
-
Bos taurus
1.6
-
Uracil
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Bos taurus
NADPH
-
Bos taurus