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Literature summary for 1.3.1.20 extracted from

  • Hung, J.J.; Chow, K.C.; Wang, H.W.; Wang, L.S.
    Expression of dihydrodiol dehydrogenase and resistance to chemotherapy and radiotherapy in adenocarcinoma cells of lung (2006), Anticancer Res., 26, 2949-2956.
    View publication on PubMed

Application

Application Comment Organism
medicine resistance to doxorubicin and cisplatin in lung adenocarcinoma cell lines is closely associated with enzyme isoforms DDH1 and DDH2 activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of enzyme in lung adenocarcinoma cell lines results in a much higher resistance to doxorubicin, cisplatin and irradiation. Isoforms DDH2 and DDH1 transfectants show higher drug and radiation resistance than DDH3 transfectants Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H1437 cell lung adenocarcinoma cell line Homo sapiens
-
NCI-H1684 cell lung adenocarcinoma cell line Homo sapiens
-
NCI-H2009 cell lung adenocarcinoma cell line Homo sapiens
-
NCI-H2087 cell lung adenocarcinoma cell line Homo sapiens
-
NCI-H2126 cell lung adenocarcinoma cell line Homo sapiens
-
NCI-H23 cell lung adenocarcinoma cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
DDH1
-
Homo sapiens
DDH2
-
Homo sapiens