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Literature summary for 1.3.1.20 extracted from

  • Carbone, V.; Hara, A.; El-Kabbani, O.
    Structural and functional features of dimeric dihydrodiol dehydrogenase (2008), Cell. Mol. Life Sci., 65, 1464-1474.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Macaca fascicularis

Protein Variants

Protein Variants Comment Organism
F279A the mutation affects inhibition and substrate affinity Macaca fascicularis
K97M mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH Macaca fascicularis
K97R mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH Macaca fascicularis
W125A the mutation affects inhibition and substrate affinity Macaca fascicularis
W254A the mutation affects inhibition and substrate affinity Macaca fascicularis

Inhibitors

Inhibitors Comment Organism Structure
2,6-dihydroxyanthraquinone competitive inhibitor Macaca fascicularis
2,6-dihydroxyanthraquinone competitive inhibitor Sus scrofa
4-hydroxyacetophenone competitive inhibitor Macaca fascicularis
4-hydroxyacetophenone competitive inhibitor Sus scrofa
isoascorbic acid competitive inhibitor Macaca fascicularis
isoascorbic acid competitive inhibitor Sus scrofa
L-ascorbic acid competitive inhibitor Macaca fascicularis
L-ascorbic acid competitive inhibitor Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Sus scrofa
Mg2+ activates Macaca fascicularis

Organism

Organism UniProt Comment Textmining
Bos taurus Q148L6
-
-
Macaca fascicularis
-
-
-
Mus musculus Q9DBB8
-
-
Pongo abelii Q5R5J5
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Macaca fascicularis
-
lens
-
Mus musculus
-
additional information not found in liver and kidney Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
camphorquinone + NAD(P)H
-
Sus scrofa (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
camphorquinone + NAD(P)H
-
Macaca fascicularis (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
camphorquinone + NAD(P)H
-
Mus musculus (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
camphorquinone + NAD(P)H
-
Pongo abelii (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
camphorquinone + NAD(P)H
-
Bos taurus (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
D-xylose + NADP+
-
Sus scrofa D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+
-
Macaca fascicularis D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+
-
Mus musculus D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+
-
Pongo abelii D-xylono-1,5-lactone + NADPH + H+
-
?
D-xylose + NADP+
-
Bos taurus D-xylono-1,5-lactone + NADPH + H+
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Sus scrofa catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Macaca fascicularis catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Mus musculus catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Pongo abelii catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Bos taurus catechol + NAD(P)H the reaction produces a ketol which then enolizes to the catechol ?

Subunits

Subunits Comment Organism
dimer x-ray crystallography Sus scrofa
dimer x-ray crystallography Macaca fascicularis

Synonyms

Synonyms Comment Organism
DHDH
-
Sus scrofa
DHDH
-
Macaca fascicularis
DHDH
-
Mus musculus
DHDH
-
Pongo abelii
DHDH
-
Bos taurus
dihydrodiol dehydrogenase
-
Sus scrofa
dihydrodiol dehydrogenase
-
Macaca fascicularis
dihydrodiol dehydrogenase
-
Mus musculus
dihydrodiol dehydrogenase
-
Pongo abelii
dihydrodiol dehydrogenase
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sus scrofa
NAD+
-
Macaca fascicularis
NAD+
-
Mus musculus
NAD+
-
Pongo abelii
NAD+
-
Bos taurus
NADP+ dependent on Sus scrofa
NADP+ dependent on Macaca fascicularis
NADP+ dependent on Mus musculus
NADP+ dependent on Pongo abelii
NADP+ dependent on Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.043
-
-
Sus scrofa isoascorbic acid
0.45
-
-
Sus scrofa L-ascorbic acid