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Literature summary for 1.3.1.21 extracted from
- Enzymatic reduction of the DELTA7 bond of 7-dehydrocholesterol (1962), J. Biol. Chem., 237, 358-362.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-dehydrocholesterol | more than 1.1 mM | Mus musculus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.14 | - |
7-dehydrocholesterol | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| additional information | subcellular localization | Mus musculus | - |
- |
| nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesta-5,7-dien-3-beta-ol + NADPH | Mus musculus | - |
cholesterol + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| kidney | low activity | Mus musculus | - |
| liver | - |
Mus musculus | - |
| spleen | low activity | Mus musculus | - |
| testis | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesta-5,7-dien-3-beta-ol + NADPH | - |
Mus musculus | cholesterol + NADP+ | - |
? | |
| cholesta-5,7-dien-3beta-ol + NADPH | - |
Mus musculus | cholesterol + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | - |
acetate buffer | Mus musculus |
| 6.2 | - |
citrate buffer | Mus musculus |
| 7.3 | - |
Tris-maleate buffer | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | low activity | Mus musculus | |
| NADPH | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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