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Literature summary for 1.3.1.21 extracted from

  • Waterham, H.R.; Wanders, R.J.A.
    Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome (2000), Biochim. Biophys. Acta, 1529, 340-356.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
sterol regulatory element-binding protein cleavage-activating protein
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae cells Homo sapiens
expression in Saccharomyces cerevisiae with c-myc epitope Rattus norvegicus
full length cDNA and 5'-terminal truncated cDNA, for the latter M59 is the first encountered, gene characterization Homo sapiens
gene characterization Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid
-
Homo sapiens
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid
-
Rattus norvegicus
EDTA
-
Homo sapiens
additional information feed-back inhibition through 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride i.e. AY-9944, hypercholesterolaemic drug Homo sapiens
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride i.e. AY-9944, hypercholesterolaemic drug Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Arabidopsis thaliana
-
-
additional information
-
Rattus norvegicus
-
-
additional information membrane topology model Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron iron-dependent Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54200
-
? * 54200, SDS-PAGE Rattus norvegicus
54500
-
? * 54500, sequence determination Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Arabidopsis thaliana
-
cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH Homo sapiens defect in cholesterol biosynthesis cause multiple congenital, developmental and morphogenic anomalies, e.g. the Smith-Lemli-Opitz syndrome due to a gene mutation, overview cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH Homo sapiens cholesterol biosynthesis cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus cholesterol biosynthesis cholesterol + NADP+
-
?
ergosta-5,7-diene-3beta-ol + NADPH Arabidopsis thaliana
-
ergosta-5-ene-3beta-ol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH
-
Arabidopsis thaliana cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH defect in cholesterol biosynthesis cause multiple congenital, developmental and morphogenic anomalies, e.g. the Smith-Lemli-Opitz syndrome due to a gene mutation, overview Homo sapiens cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH cholesterol biosynthesis Homo sapiens cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH cholesterol biosynthesis Rattus norvegicus cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH
-
Rattus norvegicus cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH wide substrate spectrum Homo sapiens cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH wide substrate spectrum Arabidopsis thaliana cholesterol + NADP+
-
?
cholesta-7-en-3beta-ol + NADPH i.e. lathosterol Homo sapiens ?
-
?
cholesta-7-en-3beta-ol + NADPH i.e. lathosterol Rattus norvegicus ?
-
?
ergosta-5,7,22-trien-3beta-ol + NADPH i.e. ergosterol Rattus norvegicus ergosta-5,22-diene-3beta-ol + NADP+
-
?
ergosta-5,7,22-trien-3beta-ol + NADPH i.e. ergosterol Arabidopsis thaliana ergosta-5,22-diene-3beta-ol + NADP+
-
?
ergosta-5,7,22-trien-3beta-ol + NADPH i.e. ergosterol Homo sapiens ergosta-5,22-diene-3beta-ol + NADP+ i.e. brassicasterol ?
ergosta-5,7-diene-3beta-ol + NADPH
-
Arabidopsis thaliana ergosta-5-ene-3beta-ol + NADP+
-
?

Subunits

Subunits Comment Organism
? ? * 54200, SDS-PAGE Rattus norvegicus
? ? * 54500, sequence determination Homo sapiens

Synonyms

Synonyms Comment Organism
7-DHCR
-
Homo sapiens
sterol DELTA7-reductase
-
Homo sapiens
sterol DELTA7-reductase
-
Rattus norvegicus
sterol DELTA7-reductase
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus
NADPH
-
Arabidopsis thaliana
NADPH strictly dependent on Homo sapiens