Activating Compound | Comment | Organism | Structure |
---|---|---|---|
sterol regulatory element-binding protein cleavage-activating protein | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae cells | Homo sapiens |
expression in Saccharomyces cerevisiae with c-myc epitope | Rattus norvegicus |
full length cDNA and 5'-terminal truncated cDNA, for the latter M59 is the first encountered, gene characterization | Homo sapiens |
gene characterization | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid | - |
Homo sapiens | |
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid | - |
Rattus norvegicus | |
EDTA | - |
Homo sapiens | |
additional information | feed-back inhibition through 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens | |
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride | i.e. AY-9944, hypercholesterolaemic drug | Homo sapiens | |
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride | i.e. AY-9944, hypercholesterolaemic drug | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Arabidopsis thaliana | - |
- |
additional information | - |
Rattus norvegicus | - |
- |
additional information | membrane topology model | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | iron-dependent | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54200 | - |
? * 54200, SDS-PAGE | Rattus norvegicus |
54500 | - |
? * 54500, sequence determination | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3-beta-ol + NADPH | Arabidopsis thaliana | - |
cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | Homo sapiens | defect in cholesterol biosynthesis cause multiple congenital, developmental and morphogenic anomalies, e.g. the Smith-Lemli-Opitz syndrome due to a gene mutation, overview | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | Homo sapiens | cholesterol biosynthesis | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | Rattus norvegicus | cholesterol biosynthesis | cholesterol + NADP+ | - |
? | |
ergosta-5,7-diene-3beta-ol + NADPH | Arabidopsis thaliana | - |
ergosta-5-ene-3beta-ol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3-beta-ol + NADPH | - |
Arabidopsis thaliana | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | defect in cholesterol biosynthesis cause multiple congenital, developmental and morphogenic anomalies, e.g. the Smith-Lemli-Opitz syndrome due to a gene mutation, overview | Homo sapiens | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | cholesterol biosynthesis | Homo sapiens | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | cholesterol biosynthesis | Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | wide substrate spectrum | Homo sapiens | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | wide substrate spectrum | Arabidopsis thaliana | cholesterol + NADP+ | - |
? | |
cholesta-7-en-3beta-ol + NADPH | i.e. lathosterol | Homo sapiens | ? | - |
? | |
cholesta-7-en-3beta-ol + NADPH | i.e. lathosterol | Rattus norvegicus | ? | - |
? | |
ergosta-5,7,22-trien-3beta-ol + NADPH | i.e. ergosterol | Rattus norvegicus | ergosta-5,22-diene-3beta-ol + NADP+ | - |
? | |
ergosta-5,7,22-trien-3beta-ol + NADPH | i.e. ergosterol | Arabidopsis thaliana | ergosta-5,22-diene-3beta-ol + NADP+ | - |
? | |
ergosta-5,7,22-trien-3beta-ol + NADPH | i.e. ergosterol | Homo sapiens | ergosta-5,22-diene-3beta-ol + NADP+ | i.e. brassicasterol | ? | |
ergosta-5,7-diene-3beta-ol + NADPH | - |
Arabidopsis thaliana | ergosta-5-ene-3beta-ol + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | ? * 54200, SDS-PAGE | Rattus norvegicus |
? | ? * 54500, sequence determination | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
7-DHCR | - |
Homo sapiens |
sterol DELTA7-reductase | - |
Homo sapiens |
sterol DELTA7-reductase | - |
Rattus norvegicus |
sterol DELTA7-reductase | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Arabidopsis thaliana | |
NADPH | strictly dependent on | Homo sapiens |