Literature summary for 1.3.1.21 extracted from

Lee, E.Y.; Shim, Y.H.; Chitwood, D.J.; Hwang, S.B.; Lee, J.; Paik, Y.K.
Cholesterol-producing transgenic Caenorhabditis elegans lives longer due to newly acquired enhanced stress resistance (2005), Biochem. Biophys. Res. Commun., 328, 929-936.

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Protein Variants

Protein Variants	Comment	Organism
additional information	expression of enzyme in Caenorhabditis elegans which is suspected to be defective in 7-dehydrocholesterol reductase activity. Caenorhabditis elegans expressing enzyme contains 80% more cholesterol than wild-type control. Brood size is reduced by 40%, although the growth rate is not significantly changed. Mean life span is increased up to 131% in sterol-deficient medium, probably resulting from acquired resisitance against both UV irradiation and thermal stress	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in Caenorhabditis elegans	-

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Release 2023.1 (January 2023)