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Literature summary for extracted from

  • Lauth, M.; Rohnalter, V.; Bergstroem, A.; Kooshesh, M.; Svenningsson, P.; Toftgard, R.
    Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels (2010), Mol. Pharmacol., 78, 486-496.
    View publication on PubMed


Cloned (Comment) Organism
expression of mouse embryonic fibroblasts, and in GLI1-positive AsPC1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockdown by DHCR7 siRNA Homo sapiens


Inhibitors Comment Organism Structure
AY9944 i.e. AY9944, competitive inhibitor of DHCR7 enzyme activity and inductor of DHCR7 expression. It blocks hedgehog signaling upstream of the Gli transcription factors, overview Homo sapiens


Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane Dhcr7 is a nine-pass transmembrane protein in the endoplasmic reticulum Homo sapiens 5789


Organism UniProt Comment Textmining
Homo sapiens
gene DHCR7

Source Tissue

Source Tissue Comment Organism Textmining
Homo sapiens
neuronal cell
Homo sapiens


Synonyms Comment Organism
Homo sapiens


Organism Comment Expression
Homo sapiens trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride, i.e. AY9944, is a competitive inhibitor of DHCR7 enzyme activity and inductor of DHCR7 expression. The DHCR7 expression is also activated by antipsychotic drugs, e.g. clozapine, chlorpromazine, haloperidol, and antidepressants such as imipramine, overview up

General Information

General Information Comment Organism
physiological function Dhcr7 inhibits hedgehog signaling in a Smo-independent manner, overview Homo sapiens