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Literature summary for extracted from

  • Najle, S.R.; Nusblat, A.D.; Nudel, C.B.; Uttaro, A.D.
    The sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske oxygenase, which is highly conserved in animals (2013), Mol. Biol. Evol., 30, 1630-1643.
    View publication on PubMed


Localization Comment Organism GeneOntology No. Textmining
Tetrahymena thermophila 16020


Organism UniProt Comment Textmining
Tetrahymena thermophila I7ML19

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + NADP+
Tetrahymena thermophila cholesta-5,7-dien-3-beta-ol + NADPH + H+


Synonyms Comment Organism
Tetrahymena thermophila

General Information

General Information Comment Organism
physiological function a knock out strain shows no differences in growth rates nor cell shape, neither in the presence nor in the absence of added sterols.Sterols found in wild-type are 83.44% cholesta-5,7,22-trien-3beta-ol as the major derivative, besides cholesterol itself, 0.55% cholesta-5,7-dien-3beta-ol and 3.84% cholesta-5,22-dien-3beta-ol. In contrast, in the KODES7 cell line, the only conversion product recovered is 92.76% 22-dehydrocholesterol Tetrahymena thermophila