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Literature summary for 1.3.1.22 extracted from

  • Moore, R.J.; Wilson, J.D.
    Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities (1976), J. Biol. Chem., 251, 5895-5900.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast cultured Homo sapiens
-
skin
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
20-alpha-hydroxypregn-4-ene-3one + NADPH
-
Homo sapiens 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+
-
?
cholest-4-en-3-one + NADPH
-
Homo sapiens 5-alpha-cholestan-3-one + NADP+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
human: 2 forms, 1. pH-optimum 5.5 (only in fibroblasts derived from genital skin), 2. pH-optimum 7-9 (in both genital and nongenital skin regions and in fibroblast from all skin regions) Homo sapiens
7 9 human: 2 forms, 1. pH-optimum 5.5 (only in fibroblasts derived from genital skin), 2. pH-optimum 7-9 (in both genital and nongenital skin regions and in fibroblast from all skin regions) Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens