Literature summary for 1.3.1.22 extracted from

Cooke, G.M.; Pothier, F.; Murphy, B.D.
The effects of progesterone, 4,16-androstadien-3-one and MK-434 on the kinetics of pig testis microsomal testosterone-4-ene 5alpha-reductase activity (1997), J. Steroid Biochem. Mol. Biol., 60, 353-359.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4,16-androstadien-3-one	-	Sus scrofa
finasteride	-	Homo sapiens
LY306089	a non steroid, non-competitive inhibitor of type I 5alpha-reductase in DU145 cells	Homo sapiens
MK434	-	Sus scrofa
progesterone	competitive	Homo sapiens
progesterone	competitive	Sus scrofa
SKF105657	a steroidal type II 5alpha-reductase specific inhibitor	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.008	-	testosterone	-	Sus scrofa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-
microsome	-	Sus scrofa	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
testosterone + NADPH + H+	-	Sus scrofa	17beta-hydroxy-5alpha-androstan-3-one + NADP+	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.7	-	in testis microsomes of 5 month-old animals	Sus scrofa
6.3	-	in testis microsomes of 6 month-old animals	Sus scrofa

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000004	-	LY306089	-	Homo sapiens
0.00086	-	progesterone	-	Sus scrofa
0.0031	-	MK434	-	Sus scrofa
0.0049	-	4,16-androstadien-3-one	-	Sus scrofa

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Release 2023.1 (January 2023)