Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dutasteride | 90% inhibition of type-2 and type-1 5alpha-reductases at clinical dosage of 0.5 mg/day | Homo sapiens | |
finasteride | 70% inhibition of type-2 5alpha-reductase at clinical dosage of 5.0 mg/day | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
prostate gland | type-2 5alpha-reductase is only found in prostate and other genital tissues, enhancement of type-1 5alpha-reductase is enhanced in prostate cancer | Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type-1 5alpha-reductase | - |
Homo sapiens |
type-2 5alpha-reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |