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Literature summary for 1.3.1.22 extracted from

  • Bratoeff, E.; Sainz, T.; Cabeza, M.; Heuze, I.; Recillas, S.; Perez, V.; Rodriguez, C.; Segura, T.; Gonzales, J.; Ramirez, E.
    Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5alpha-reductase (2007), J. Steroid Biochem. Mol. Biol., 107, 48-56.
    View publication on PubMed
Search for more literature for 1.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione
-
 Homo sapiens
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione
-
 Mesocricetus auratus
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Homo sapiens
17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Mesocricetus auratus
17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Homo sapiens
17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
-
 Mesocricetus auratus
dutasteride
-
 Homo sapiens
dutasteride
-
 Mesocricetus auratus
finasteride
-
 Homo sapiens
finasteride
-
 Mesocricetus auratus
turosteride
-
 Homo sapiens
turosteride
-
 Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Mesocricetus auratus 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mesocricetus auratus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
 Homo sapiens
-
prostate gland
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
 ?
testosterone + NADPH + H+
-
 Mesocricetus auratus 5alpha-dihydrotestosterone + NADP+
-
 ?
testosterone + NADPH + H+
-
 Homo sapiens 5alpha-dihydrotestosterone + NADP+ + H+
-
 ?
testosterone + NADPH + H+
-
 Mesocricetus auratus 5alpha-dihydrotestosterone + NADP+ + H+
-
 ?

Synonyms

Synonyms Comment Organism
steroid 5alpha-reductase
-
 Homo sapiens
steroid 5alpha-reductase
-
 Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Mesocricetus auratus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000085
-
 in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 Homo sapiens finasteride
0.0000085
-
 with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C Homo sapiens finasteride
0.00001
-
 in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 Homo sapiens 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
0.00001
-
 with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C Homo sapiens 17alpha-phenylcarbamoyloxy-4-pregnen-3,20-dione
0.00005
-
 in the presence of 1 mM dithiothreitol, in 40 mM sodium phosphate buffer, at pH 6.5 Homo sapiens 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3 20-dione
0.00005
-
 with 1 mM dithiothreitol in 40 mM sodium phosphate buffer, at pH 6.5 and 37°C Homo sapiens 17alpha-p-bromophenylcarbamoyloxy-4-pregnen-3,20-dione