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Literature summary for 1.3.1.22 extracted from
- The rationale for inhibiting 5alpha-reductase isoenzymes in the prevention and treatment of prostate cancer (2008), J. Urol., 179, 1235-1242.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | 5alpha reductase inhibitors decrease prostate volume and induce atrophy and apoptosis in benign prostatic epithelium | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dutasteride | dual 5alpha-reductase inhibitor, 45fold more effective in inhibiting type 1 5alpha-reductase and 2fold more effective in inhibiting type 2 5alpha-reductase than finasteride | Homo sapiens |  |
| dutasteride | dual 5alpha-reductase inhibitor | Rattus norvegicus | |
| finasteride | type 2 5alpha-reductase inhibitor | Homo sapiens | |
| finasteride | type 2 5alpha-reductase inhibitor | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate cancer cell | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ + H+ | - |
? | |
| testosterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-dihydrotestosterone + NADP+ + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5alphaR1 | - |
Homo sapiens |
| 5alphaR1 | - |
Rattus norvegicus |
| 5alphaR2 | - |
Homo sapiens |
| 5alphaR2 | - |
Rattus norvegicus |
| type 1 5alpha-reductase | isoenzyme | Homo sapiens |
| type 1 5alpha-reductase | isoenzyme | Rattus norvegicus |
| type 1 5alphaR | - |
Homo sapiens |
| type 1 5alphaR | - |
Rattus norvegicus |
| type 2 5alpha-reductase | isoenzyme | Homo sapiens |
| type 2 5alpha-reductase | isoenzyme | Rattus norvegicus |
| type 2 5alphaR | - |
Homo sapiens |
| type 2 5alphaR | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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