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Literature summary for 1.3.1.22 extracted from
- Oxytocin increases 5alpha -reductase activity of human prostate epithelial cells, but not stromal cells (2008), Prostate, 68, 115-121.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | oxytocin does not stimulate enzyme activity or expression in human prostate epithelial cells | Homo sapiens | |
| Oxytocin | increases activity in human prostate epithelial cells | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| PrEC cell | - |
Homo sapiens | - |
| prostate epithelium | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| prostate stroma cell | - |
Homo sapiens | - |
| PrSC cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-alpha reductase I | isozyme | Homo sapiens |
| 5-alpha reductase II | isozyme | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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