Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.24 extracted from

  • Maghzal, G.J.; Leck, M.C.; Collinson, E.; Li, C.; Stocker, R.
    Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase (2009), J. Biol. Chem., 284, 29251-29259.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
into the pGEM-T easy vector, subcloned into the vectors pcDNA3 and pESC-LEU Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bilirubin + NADP+ Homo sapiens
-
biliverdin + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0001
-
HeLa cells transfected with BVR-targeted RNAi Homo sapiens
0.00035
-
BVR activity in HeLa cells, control Homo sapiens
0.00075
-
HeLa cells transfected with pcDNA3-BVR, overexpression of BVR Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + NADP+
-
Homo sapiens biliverdin + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
biliverdin reductase
-
Homo sapiens
BVR
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
activity assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens