Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
macrophage | lung | Homo sapiens | - |
macrophage | increased expression in macrophages of primary spontaneous pneumothorax of smokers compared to non-smokers | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
biliverdin reductase | - |
Homo sapiens |
BVR | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | oxidative stress induces HO-1, BVR and H-ferritin in lung macrophages, this is involved in development of primary spontaneous pneumothorax disease, overview. HIF-1alpha siRNA transfection completely abrogated the increased HO-1, BVR and H-ferritin mRNA levels | up |
Homo sapiens | increased expression in macrophages of primary spontaneous pneumothorax of smokers compared to non-smokers | up |
General Information | Comment | Organism |
---|---|---|
metabolism | HIF-1alpha regulates the expression of BVR and other enzymes involved in oxidative stress response in lung macrophages, overview | Homo sapiens |
physiological function | primary spontaneous pneumothorax, PSP, in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin. Cigarette smoke is a risk factor of recurrence of the disease, overview | Homo sapiens |