Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.24 extracted from

  • Goven, D.; Boutten, A.; Lecon-Malas, V.; Marchal-Somme, J.; Soler, P.; Boczkowski, J.; Bonay, M.
    Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha (2010), PLoS ONE, 5, e10886.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-
macrophage lung Homo sapiens
-
macrophage increased expression in macrophages of primary spontaneous pneumothorax of smokers compared to non-smokers Homo sapiens
-

Synonyms

Synonyms Comment Organism
biliverdin reductase
-
Homo sapiens
BVR
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens oxidative stress induces HO-1, BVR and H-ferritin in lung macrophages, this is involved in development of primary spontaneous pneumothorax disease, overview. HIF-1alpha siRNA transfection completely abrogated the increased HO-1, BVR and H-ferritin mRNA levels up
Homo sapiens increased expression in macrophages of primary spontaneous pneumothorax of smokers compared to non-smokers up

General Information

General Information Comment Organism
metabolism HIF-1alpha regulates the expression of BVR and other enzymes involved in oxidative stress response in lung macrophages, overview Homo sapiens
physiological function primary spontaneous pneumothorax, PSP, in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin. Cigarette smoke is a risk factor of recurrence of the disease, overview Homo sapiens