Application | Comment | Organism |
---|---|---|
medicine | role for bile acids in inhibiting hepatic glucocorticoid clearance, of sufficient magnitude to suppress hypothalamic-pituitary-adrenal axis activity. Elevated hepatic bile acids may account for adrenal insufficiency in liver disease | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chenodeoxycholic acid | competitively inhibits 5beta-reductase | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0092 | - |
chenodeoxycholic acid | pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | presence of chenodeoxycholic acid reduces transcript abundance in H4iiE cell and promoter activity in HepG2 cells | down |