Cloned (Comment) | Organism |
---|---|
expression of splice variant AKR1D1 in HEK-293 cell | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51857 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | splice variants AKR1D1-002 and AKR1D1-001 are expressed in liver | Homo sapiens | - |
testis | only splice variant AKR1D1-006 is expressed in testis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dexamethasone + NADPH + H+ | substrate of splice variant AKR1D1-002 | Homo sapiens | ? + NADP+ | - |
? | |
additional information | splice variant AKR1D1-002 efficiently metabolizes glucocorticoids and androgens and decreases receptor activation. Variants AKR1D1-001 and AKR1D1-006 poorly metabolize dexamethasone, but do not metabolize cortisol, prednisolone, testosterone or androstenedione | Homo sapiens | ? | - |
- |
|
prednisolone + NADPH + H+ | substrate of splice variant AKR1D1-002 | Homo sapiens | ? + NADP+ | - |
? | |
testosterone + NADPH + H+ | substrate of splice variant AKR1D1-002 | Homo sapiens | (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+ | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | treatment of cells with proteasomal inhibitor, MG-132 increases expression of splice variants AKR1D1-001 and AKR1D1-006 | up |