Literature summary for 1.3.1.3 extracted from

Valanejad, L.; Nadolny, C.; Shiffka, S.; Chen, Y.; You, S.; Deng, R.
Differential feedback regulation of Delta4-3-oxosteroid 5beta-reductase expression by bile acids (2017), PLoS ONE, 12, e0170960 .

Search for more literature for 1.3.1.3

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P51857	-	-
Mus musculus	Q8VCX1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
AKR1D1	-	Homo sapiens
AKR1D1	-	Mus musculus

Expression

Organism	Comment	Expression
Homo sapiens	chenodeoxycholic acid markedly represses AKR1D1 expression in vitro in human hepatoma Hep-G2 cells, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway	down
Mus musculus	chenodeoxycholic acid markedly represses AKR1D1 expression, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway	down
Homo sapiens	cholic acid significantly upregulates AKR1D1 expression in HepG2 cells, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway	up
Mus musculus	cholic acid significantly upregulates AKR1D1 expression, regulation occurs through the mitogen-activated protein kinases/c-Jun Nterminal kinases (MAPK/JNK) signaling pathway	up

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Release 2023.1 (January 2023)