Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | 0.1 mM, 86% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 | Bos taurus | |
Disulfiram | 0.1 mM, 61% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 | Bos taurus | |
indomethacin | 0.1 mM, 97% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 | Bos taurus | |
quercitrin | 0.1 mM, 76% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2 | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Bos taurus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
gel filtration | Bos taurus |
57000 | - |
1 * 57000, SDS-PAGE | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ciliary body | - |
Bos taurus | - |
cornea | - |
Bos taurus | - |
iris | - |
Bos taurus | - |
retina | retinal pigment epithelium choroid | Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00026 | - |
enzyme activity in cornea, substrate 15-ketoprostaglandin, cofactor NADPH | Bos taurus |
0.000389 | - |
enzyme activity in retina, substrate 15-ketoprostaglandin, cofactor NADPH | Bos taurus |
0.00085 | - |
enzyme activity in retinal pigment epithelium, substrate 15-ketoprostaglandin, cofactor NADPH | Bos taurus |
0.000945 | - |
enzyme purified from iris-ciliary cytosol | Bos taurus |
0.0012 | - |
enzyme activity in ciliary body, substrate 15-ketoprostaglandin, cofactor NADPH | Bos taurus |
0.00145 | - |
enzyme activity in iris, substrate 15-ketoprostaglandin, cofactor NADPH | Bos taurus |
Storage Stability | Organism |
---|---|
-80°C, NADH-linked activity is lost overnight | Bos taurus |
0°C, NADPH-linked activity is lost after a few hours | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid + NAD(P)H | - |
Bos taurus | 11-hydroxy-9,15-dioxoprosta-5-en-1-oic acid + NAD(P)+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 57000, SDS-PAGE | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)H | enzyme from iris-ciliary body prefers NADPH | Bos taurus |