Cloned (Comment) | Organism |
---|---|
recombinant expression as GST-tagged enzyme in Escherichiacoli strain BL-21LysS | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(2-chloro-3-((4-methylcyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(1-cyclopropylethoxy)benzylidene)-1,3- thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(2-cyclohexylethoxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(3-cyclohexylpropoxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione | the compound significantly increases the level of PGE2 in skin defects | Homo sapiens | |
5-(2-chloro-3-(4-cyclohexylbutoxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(cyclohexylmethoxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(cyclohexyloxy)benzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-(cyclopentyloxy)benzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(2-chloro-3-phenethoxybenzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(3-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione | - |
Homo sapiens | |
5-(3-(bicyclo[2.2.1]hept-2-ylmethoxy)-2-chlorobenzylidene)-1,3-thiazolidine-2,4-dione | - |
Homo sapiens | |
ciglitazone | - |
Homo sapiens | |
additional information | thiazolidinediones as enzyme inhibitors. No inhibition by 5-(2-chloro-3-(1-cyclopropylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | Homo sapiens | |
thiazolidinedione | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostaglandin E2 + NADP+ | Homo sapiens | - |
15-ketoprostaglandin E2 + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HaCaT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prostaglandin E2 + NADP+ | - |
Homo sapiens | 15-ketoprostaglandin E2 + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
15-PGDH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.000029 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(2-cyclohexylethoxy)benzylidene)thiazolidine-2,4-dione | |
0.000045 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione | |
0.000054 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione | |
0.000058 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(cyclohexylmethoxy)benzylidene)thiazolidine-2,4-dione | |
0.000059 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(3-cyclohexylpropoxy)benzylidene)thiazolidine-2,4-dione | |
0.000095 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(4-cyclohexylbutoxy)benzylidene)thiazolidine-2,4-dione | |
0.000122 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-phenethoxybenzylidene)thiazolidine-2,4-dione | |
0.00013 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00014 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-((4-methylcyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00014 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00015 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00017 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.000212 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(cyclohexyloxy)benzylidene)thiazolidine-2,4-dione | |
0.00023 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.000257 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(3-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione | |
0.00036 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00109 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00258 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(cyclopentyloxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.00862 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(3-(bicyclo[2.2.1]hept-2-ylmethoxy)-2-chlorobenzylidene)-1,3-thiazolidine-2,4-dione | |
0.0103 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione | |
0.0117 | - |
pH 75, 37°C, recombinant GST-tagged enzyme | Homo sapiens | 5-(2-chloro-3-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione |
General Information | Comment | Organism |
---|---|---|
physiological function | prostaglandin E2, PGE2, has a short half-life in vivo because is rapidly oxidized to 15-ketoprostaglandins by the cytosolic enzyme 15-PGDH. PGE2 acts through EP2 and EP4 receptors to mediate regeneration and hematopoietic stem cell development via the Wnt signaling pathway. Wnt activation in stem cells requires PGE2, and the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery. PGE2 regulates vertebrate hematopoietic stem cell induction and engraftment | Homo sapiens |