Literature summary for 1.3.1.54 extracted from

Kiuchi, F.; Thibaut, D.; Debussche, L.; Leeper, F.; Blanche, F.; Battersby, A.R.
Biosynthesis of vitamin B12: stereochemistry of transfer of a hydride equivalent from NADPH by precorrin-6x reductase (1992), J. Chem. Soc., Chem. Commun., 306-308.

No PubMed abstract available

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
precorrin-6A + NADPH	Pseudomonas denitrificans (nom. rej.)	step in the biosynthesis of cobalamine, vitamin B12	precorrin-6B + NADP+	-	?
precorrin-6A + NADPH	Pseudomonas denitrificans (nom. rej.) SC510 Rif	step in the biosynthesis of cobalamine, vitamin B12	precorrin-6B + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas denitrificans (nom. rej.)	-	-	-
Pseudomonas denitrificans (nom. rej.) SC510 Rif	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
precorrin-6B + NADP+ = precorrin-6A + NADPH + H+	reaction mechanism	Pseudomonas denitrificans (nom. rej.)	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
precorrin-6A + NADPH	step in the biosynthesis of cobalamine, vitamin B12	Pseudomonas denitrificans (nom. rej.)	precorrin-6B + NADP+	-	?
precorrin-6A + NADPH	stereospecific hydride transfer from NADPH to the enzyme, NMR analysis of reaction product, deuterium-labeling	Pseudomonas denitrificans (nom. rej.)	precorrin-6B + NADP+	-	?
precorrin-6A + NADPH	step in the biosynthesis of cobalamine, vitamin B12	Pseudomonas denitrificans (nom. rej.) SC510 Rif	precorrin-6B + NADP+	-	?
precorrin-6A + NADPH	stereospecific hydride transfer from NADPH to the enzyme, NMR analysis of reaction product, deuterium-labeling	Pseudomonas denitrificans (nom. rej.) SC510 Rif	precorrin-6B + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
precorrin-6x reductase	-	Pseudomonas denitrificans (nom. rej.)

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Pseudomonas denitrificans (nom. rej.)

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Release 2023.1 (January 2023)