Literature summary for 1.3.1.6 extracted from

Mori, M.; Morimoto, H.; Kim, Y.; Ui, H.; Nonaka, K.; Masuma, R.; Sakamoto, K.; Kita, K.; Tomoda, H.; Shiomi, K.; Omura, S.
Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389 (2011), Tetrahedron, 67, 6582-6586.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ukulactone A	polyketide isolated from a culture broth of Penicillium sp. FKI-3389, shows potent inhibitory activity	Ascaris suum
ukulactone B	polyketide isolated from a culture broth of Penicillium sp. FKI-3389. Inhibitory activity is 200 times weaker than that of epimer ukulactone A	Ascaris suum

Organism

Organism	UniProt	Comment	Textmining
Ascaris suum	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000024	-	pH 7.0, 37°C	Ascaris suum	ukulactone A
0.00047	-	pH 7.0, 37°C	Ascaris suum	ukulactone B

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Release 2023.1 (January 2023)