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Literature summary for 1.3.1.70 extracted from

  • He, J.X.; Fujioka, S.; Li, T.C.; Kang, S.G.; Seto, H.; Takatsuto, S.; Yoshida, S.; Jang, J.C.
    Sterols regulate development and gene expression in Arabidopsis (2003), Plant Physiol., 131, 1258-1269.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.70

Activating Compound

Activating Compound Comment Organism Structure
additional information brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information mutational blockage of the enzyme leads to accumulation of atypical products from substrate 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol in vivo, i.e. 5alpha-cholesta-8,14-dien-3beta-ol, (24R)-5alpha-ergosta-8,14-dien-3beta-ol, and (24R)-5alpha-stigmasta-8,14-dien-3beta-ol Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
fenpropimorph impairs cell expansion and affects gene expression in vivo, the effects cannot be reversed by addition of exogenous brassicasterols, changes sterol composition, phenotype is similar to fk-mutant plants, molecular mechanism Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+ Arabidopsis thaliana step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK 4alpha-methylfecosterol + NADP+
-
 ?
isofucosterol + NADPH Arabidopsis thaliana step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1 sitosterol + NADP+
-
 ?
additional information Arabidopsis thaliana brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 gene fk, enzyme FK, and bifunctinal enzyme DIM1/CBB1/DWF1
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information fk gene expression pattern in wild-type and mutant strains, regulatory effects of sterols, overview Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
-
 Arabidopsis thaliana 4alpha-methylfecosterol + NADP+
-
 ?
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+ step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK Arabidopsis thaliana 4alpha-methylfecosterol + NADP+
-
 ?
isofucosterol + NADPH
-
 Arabidopsis thaliana sitosterol + NADP+
-
 ?
isofucosterol + NADPH step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1 Arabidopsis thaliana sitosterol + NADP+
-
 ?
additional information brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
FK
-
 Arabidopsis thaliana
sterol C-14 reductase
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Arabidopsis thaliana