BRENDA - Enzyme Database
show all sequences of 1.3.1.70

Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase

Hata, M.; Ishii, Y.; Watanabe, E.; Uoto, K.; Kobayashi, S.; Yoshida, K.; Otani, T.; Ando, A.; Med. Mycol. 48, 613-621 (2010)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Saccharomyces cerevisiae
Candida albicans
Inhibitors
Inhibitors
Commentary
Organism
Structure
4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
using a genetic aproach in Saccharomyces cerevisiae it is shown that ERG24 is the target enzyme of compound 4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
Candida albicans
amorolfine
-
Candida albicans
Organism
Organism
UniProt
Commentary
Textmining
Candida albicans
-
-
-
Synonyms
Synonyms
Commentary
Organism
C-14 reductase
-
Candida albicans
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Saccharomyces cerevisiae
Candida albicans
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
using a genetic aproach in Saccharomyces cerevisiae it is shown that ERG24 is the target enzyme of compound 4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
Candida albicans
amorolfine
-
Candida albicans
Other publictions for EC 1.3.1.70
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746161
Huang
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939-950
2017
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744648
Bartoli
Impaired cell proliferation i ...
Mus musculus
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2164-2173
2016
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Li
Structure of an integral memb ...
Methylomicrobium alcaliphilum 20Z, Methylomicrobium alcaliphilum
Nature
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104-107
2015
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1
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3
3
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725903
Liu
A sterol C-14 reductase encode ...
Fusarium graminearum
Microbiology
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1665-1675
2011
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711302
Schiavoni
Activation of TM7SF2 promoter ...
Homo sapiens
Biochim. Biophys. Acta
1801
587-592
2010
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Wang
Gonadotropin-regulated express ...
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25-32
2010
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1
1
1
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725863
Hata
Inhibition of ergosterol synth ...
Candida albicans
Med. Mycol.
48
613-621
2010
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1
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2
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5
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723885
Liang
2-Amino-nonyl-6-methoxyl-tetra ...
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Acta Pharmacol. Sin.
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1709
2009
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688770
Shah Alam Bhuiyan
Synthetically lethal interacti ...
Saccharomyces cerevisiae
Lipids
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69-76
2007
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672378
Bennati
Sterol dependent regulation of ...
Homo sapiens
Biochim. Biophys. Acta
1761
677-685
2006
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1
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22
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4
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4
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1
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2
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22
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4
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655352
Yamashita
Gonadotropin-induced DELTA14-r ...
Sus scrofa
Endocrinology
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1
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4
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2
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1
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654166
Waterham
Autosomal recessive HEM/Greenb ...
Homo sapiens
Am. J. Hum. Genet.
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1013-1017
2003
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1
1
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3
1
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657046
He
Sterols regulate development a ...
Arabidopsis thaliana
Plant Physiol.
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1258-1269
2003
1
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1
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1
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3
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1
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5
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288492
Roberti
Cloning and expression of ster ...
Bos taurus, Homo sapiens
Eur. J. Biochem.
269
283-290
2002
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2
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6
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2
4
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7
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1
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3
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12
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1
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1
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2
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2
2
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6
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2
4
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1
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3
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12
-
1
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1
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654204
Jia
Candida albicans sterol C-14 r ...
Candida albicans
Antimicrob. Agents Chemother.
46
947-957
2002
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1
1
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1
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13
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1
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1
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1
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1
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1
1
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13
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1
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1
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1
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656304
Prakash
Genes encoding chimeras of Neu ...
Homo sapiens, Neurospora crassa
J. Biosci.
27
105-112
2002
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2
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3
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8
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1
-
1
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2
-
3
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2
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2
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1
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2
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656798
Prakash
The sterol C-14 reductase enco ...
Neurospora crassa
Mol. Genet. Genomics
266
787-795
2002
-
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1
-
38
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1
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3
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1
-
1
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2
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1
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1
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1
1
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38
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1
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1
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1
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2
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288491
Kim
Cholesterol biosynthesis from ...
Rattus norvegicus
Biochim. Biophys. Acta
1259
39-48
1995
4
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2
7
1
2
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2
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3
-
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1
1
-
3
1
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5
1
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1
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1
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4
4
-
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1
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2
4
7
-
1
2
-
2
3
-
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-
1
-
3
1
-
5
1
1
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-
288494
Lorenz
Cloning, sequencing, and disru ...
Saccharomyces cerevisiae
DNA Cell Biol.
11
685-692
1992
-
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1
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2
-
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1
2
-
2
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3
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3
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1
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3
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288493
Taton
Microsomal DELTA8,14-sterol DE ...
Embryophyta, Zea mays
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185
605-614
1989
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1
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-
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28
5
6
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5
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4
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2
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1
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16
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1
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2
3
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5
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1
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4
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5
28
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5
6
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5
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1
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16
-
1
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2
3
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288495
Baloch
-
Inhibition of sterol DELTA8 -> ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae NCYC 739, Ustilago maydis
Phytochemistry
26
663-668
1987
-
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6
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2
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3
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1
1
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4
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1
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1
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3
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2
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3
6
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1
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1
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288490
Paik
Microsomal enzymes of choleste ...
Rattus norvegicus
J. Biol. Chem.
259
13413-13423
1984
2
1
-
-
-
3
12
5
4
1
-
4
-
2
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-
1
1
-
1
1
2
15
-
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1
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1
2
-
2
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2
1
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2
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3
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12
-
5
4
1
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4
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1
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1
1
2
15
-
1
-
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-
1
2
-
-
-
-
-
-
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-
288489
Bottema
DELTA14-Sterol reductase in Sa ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae 3701B
Biochim. Biophys. Acta
531
301-307
1978
2
-
-
-
-
1
5
2
2
-
-
6
-
4
-
-
1
-
-
-
-
-
11
-
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1
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1
1
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1
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2
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1
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1
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5
-
2
2
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6
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1
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11
-
1
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1
1
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