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Literature summary for extracted from

  • Mirza, R.; Hayasaka, S.; Takagishi, Y.; Kambe, F.; Ohmori, S.; Maki, K.; Yamamoto, M.; Murakami, K.; Kaji, T.; Zadworny, D.; Murata, Y.; Seo, H.
    DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis (2006), J. Invest. Dermatol., 126, 638-647.
    View publication on PubMed


Application Comment Organism
medicine DHCR24 plays crucial role for skin development and its proper function Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information DHCR24 knockout mice, development of the epidermis, especially keratinization, is impaired, altered expression of filaggrin, loricrin, and involcrin, transepidermal water loss is markedly increased, impaired skin barrier function Mus musculus


Organism UniProt Comment Textmining
Mus musculus Q8VCH6

Source Tissue

Source Tissue Comment Organism Textmining
epidermis abundantly expressed throughout the epidermis except for the stratum corneum and in hair follicles Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
desmosterol + NADPH
Mus musculus cholesterol + NADP+


Synonyms Comment Organism
3beta-hydroxysterol-delta24 reductase
Mus musculus
Mus musculus