Application | Comment | Organism |
---|---|---|
medicine | surface DHCR24 can be a valuable target for hepatitis C virus-related hepatocellular carcinoma therapy, and 2-152a MAb appears to be useful for this targeted therapy | Homo sapiens |
pharmacology | 3beta-hydroxysterol DELTA24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a specific chimeric antibody 2-152a MAb | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | hepatocellular carcinoma cells, hepatoblastoma cell line, and cervical adenocarcinoma-derived cell line | Homo sapiens | 9986 | - |
endoplasmic reticulum membrane | primarily, a putative transmembrane domain exists in the N-terminus of DHCR24 | Homo sapiens | 5789 | - |
additional information | no DHCR24 expression on the surface of the normal human hepatocyte lines NKNT and TTNT | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15392 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
HEP-3B cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
hepatocellular carcinoma cell | DHCR24 is specifically expressed on the surface of HCC cell lines | Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysterol DELTA24-reductase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | DHCR24 is overexpressed in hepatitis C virus-related hepatocellular carcinoma specifically induced by hepatitis C virus | up |
General Information | Comment | Organism |
---|---|---|
malfunction | 2-152a MAb-mediated binding of a cytotoxic agent (a saponin-conjugated secondary antibody) to surface DHCR24 leads to significant cytotoxicity. HCV replication can be suppressed by inhibiting DHCR24 with an enzymatic inhibitor | Homo sapiens |
physiological function | surface DHCR24 on hepatocellular carcinoma cells can function as a carrier for internalization, e.g. of hepatitis C virus, HCV. DHCR24-mediated cholesterol biosynthesis plays a crucial role in the HCV life cycle. Antibody 2-152a MAb-mediated binding of 2ndAb-Sap to surface DHCR24 on hepatocellular carcinoma cells predicted to lead to internalization of 2ndAb-Sap and subsequent cell death | Homo sapiens |