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Literature summary for 1.3.1.85 extracted from

  • Alber, B.E.
    Biotechnological potential of the ethylmalonyl-CoA pathway (2010), Appl. Microbiol. Biotechnol., 89, 17-25.
    View publication on PubMed
Search for more literature for 1.3.1.85

Organism

Organism UniProt Comment Textmining
Cereibacter sphaeroides
-
-
-
Methylorubrum extorquens
-
-
-
Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + CO2 + NADPH + H+
-
 Cereibacter sphaeroides (2S)-ethylmalonyl-CoA + NADP+
-
 r
crotonyl-CoA + CO2 + NADPH + H+
-
 Streptomyces coelicolor (2S)-ethylmalonyl-CoA + NADP+
-
 r
crotonyl-CoA + CO2 + NADPH + H+
-
 Methylorubrum extorquens (2S)-ethylmalonyl-CoA + NADP+
-
 r
additional information the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate Cereibacter sphaeroides ?
-
 ?
additional information the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate Streptomyces coelicolor ?
-
 ?
additional information the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate Methylorubrum extorquens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Cereibacter sphaeroides
NADP+
-
 Streptomyces coelicolor
NADP+
-
 Methylorubrum extorquens
NADPH
-
 Cereibacter sphaeroides
NADPH
-
 Streptomyces coelicolor
NADPH
-
 Methylorubrum extorquens

Expression

Organism Comment Expression
Cereibacter sphaeroides although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate up
Streptomyces coelicolor although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate up
Methylorubrum extorquens although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate up

General Information

General Information Comment Organism
metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway Cereibacter sphaeroides
metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway Streptomyces coelicolor
metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway Methylorubrum extorquens