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Literature summary for 1.3.1.86 extracted from

  • Strom, K.A.; Kumar, S.
    Activation and inhibition of crotonyl-coenzyme A reductase activity of bovine mammary fatty acid synthetase (1979), J. Biol. Chem., 254, 8159-8162.
No PubMed abstract available
Search for more literature for 1.3.1.86

Activating Compound

Activating Compound Comment Organism Structure
CoA free CoA is a strong activator of the reductase reaction Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
2-methylcrotonyl-CoA CoA-activated enzyme shows competitive inhibition with the substrate analog 2-methylcrotonyl-CoA Bos taurus
4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole extremely potent inhibitor Bos taurus
5,5'-dithiobis(2-nitrobenzoic acid) extremely potent inhibitor Bos taurus
acetyl-CoA competitive inhibitor Bos taurus
butyryl-CoA competitive inhibitor Bos taurus
iodoacetamide
-
 Bos taurus
iodoacetate
-
 Bos taurus
malonyl-CoA noncompetitive inhibitor Bos taurus
N-ethylmaleimide extremely potent inhibitor Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland
-
 Bos taurus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0029
-
 2-methylcrotonyl-CoA pH and temperature not specified in the publication Bos taurus
0.005
-
 butyryl-CoA pH and temperature not specified in the publication Bos taurus
0.006
-
 acetyl-CoA pH and temperature not specified in the publication Bos taurus
0.021
-
 malonyl-CoA pH and temperature not specified in the publication Bos taurus