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Literature summary for 1.3.1.9 extracted from

  • Bonnac, L.; Gao, G.Y.; Chen, L.; Felczak, K.; Bennett, E.M.; Xu, H.; Kim, T.; Liu, N.; Oh, H.; Tonge, P.J.; Pankiewicz, K.W.
    Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis (2007), Bioorg. Med. Chem. Lett., 17, 4588-4591.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-phenoxybenzamide adenine dinucleotide NAD analogue which mimics isoniazid-NAD adduct Mycobacterium tuberculosis
5-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-phenoxybenzamide 25% inhibition at 0.7 mM Mycobacterium tuberculosis
[5-(3-carbamoyl-4-phenoxyphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate 12% inhibition at 0.1 mM Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGR1
-
-
Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+
-
Mycobacterium tuberculosis trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
?
acyl-[acyl-carrier protein] + NAD+
-
Mycobacterium tuberculosis H37Rv trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
InhA
-
Mycobacterium tuberculosis
NAD-dependent enoyl-ACP reductase
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.027
-
-
Mycobacterium tuberculosis 4-phenoxybenzamide adenine dinucleotide